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NVIDIA Foundation Awards $200K Grant in “Compute the Cure” Anti-Cancer Effort

         

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Lung most cancers. Colon most cancers. Breast most cancers. Greater than forty years into the “Warfare on Most cancers,” the deadliest types of the illness are nonetheless killing a whole bunch of hundreds of individuals within the U.S. every year.

Whereas the struggle towards most cancers now and again appears to have reached a stalemate, researchers the use of highly effective pc simulations have executed a string of breakthroughs over the last few years. The end result: fashions that disclose the mechanisms that enable one of the most deadliest varieties of most cancers to boost in molecule-via-molecule element.

Dr. Rommie Amaro, on the College of California, San Diego, hopes to make use of that new working out to lend a hand unencumber new most cancers therapies.

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Doctor Rommie Amaro

To further that work, the NVIDIA Foundation, as part of our “Compute the Cure” initiative, has awarded Amaro and her team a grant of $200,000. They’ll use it to focus on developing a computer-aided drug design platform to help researchers take advantage of computer simulations to find promising cancer treatment drugs.

“This is an exciting time, because we’re better able to simulate how the dynamics of these drug targets actually evolve over time,” Amaro says. “As a result, we should be able to design more selective drugs with better affinity using this information.”

Amaro is one of a team of researchers who have used computer simulations to better understand the behavior of a human protein key to shutting down mutated cells – known as p53 – involved in more than half of all human cancers. These simulations capture not just how proteins are built, but how they function inside the body.

Computer simulations have allowed researchers to not only understand the structure of this tumor-fighting protein, but how this tumor-fighting protein behaves within the body. This discovery revealed a new “binding site” that may allow cancer researchers to create new drugs that can help when p53 doesn’t do its job.

Her group’s latest effort aims to incorporate cutting-edge GPU technology into shareable computer-aided drug discovery workflows that her team is building. The workflows are like recipes that researchers can follow to find new drug targets or reproduce the work done by their peers.

“We aim to disseminate these complex computational drug discovery experiments in a way that makes them much more accessible to the broader research community,” Amaro says. “And because we’re using GPU technology, it will be much faster than it was before.”

Amaro is one of a new generation of scientists who see computer simulation as a key scientific tool. The daughter of a math teacher, Amaro – who worked at Kraft Foods creating processes that could be used to mass produce new kinds of Philadelphia Cream Cheese before going on to get her Ph.D. – is known for mixing the theoretical and the practical.

Her focus on the intersection of new computational methods, drug discovery and molecular-level biophysics has won wide recognition. In 2011, she received the Presidential Early Career Award for Scientists and Engineers. In 2010, she was named a National Institutes of Health New Innovator for her work at the intersection of computing and drug discovery.

That work is a perfect fit for our Compute the Cure initiative, an effort that flows from our employee-led NVIDIA Foundation’s focus on health – one driven by surveys that show health issues are a major concern for NVIDIANs around the world.

Compute the Cure focuses on projects that use the parallel computing technology that underpins all our products to have a dramatic impact on the battle against cancer, efforts that are on the cusp of yielding new breakthroughs in cancer treatment and diagnostics.

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